Undisturbed climbing fiber pruning in the cerebellar cortex of CX 3 CR1 ‐deficient mice
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چکیده
منابع مشابه
Latencies of climbing fiber inputs to turtle cerebellar cortex.
Responses of separate regions of rat cerebellar cortex (Cb) to inferior olive (IO) stimulation occur with the same latency despite large differences in climbing fiber (CF) lengths. Here, the olivocerebellar path of turtle was studied because its Cb is an unfoliated sheet on which measurements of latency and CF length can be made directly across its entire surface in vitro. During extracellular ...
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The physiology of climbing fiber signals in cerebellar Purkinje cells has been studied since the early days of electrophysiology. Both the climbing fiber-evoked complex spike and the role of climbing fiber activity in the induction of long-term depression (LTD) at parallel fiber-Purkinje cell synapses have become hallmark features of cerebellar physiology. However, the key role of climbing fibe...
متن کاملDifferential maturation of climbing fiber innervation in cerebellar vermis.
Folding of the brain surface is a general morphological adaptation to maximize surface area in a limited cranial volume. Surface folding is present not only in the neocortex but also in the cerebellar cortex. This folding creates subdivisions of the cortical surface: the sulci, the gyri, and the straight bank region, which is interposed. Is cortical folding only the solution to a surface-volume...
متن کاملEthanol affects NMDA receptor signaling at climbing fiber - 3 Purkinje cell synapses in mice and impairs cerebellar LTD
1 2 Ethanol affects NMDA receptor signaling at climbing fiber 3 Purkinje cell synapses in mice and impairs cerebellar LTD 4 5 6 Qionger He, Heather Titley, Giorgio Grasselli, Claire Piochon 7 and Christian Hansel 8 9 Department of Neurobiology, University of Chicago, Chicago, Illinois, USA 10 11 12 13 14 15 16 Running head: Ethanol affects Purkinje cell NMDA receptors 17 18 Corresponding author...
متن کاملClimbing fiber synapse elimination in cerebellar Purkinje cells.
Innervation of Purkinje cells (PCs) by multiple climbing fibers (CFs) is refined into mono-innervation during the first three postnatal weeks of rodents' lives. In this review article, we will integrate the current knowledge on developmental process and mechanisms of CF synapse elimination. In the 'creeper' stage of CF innervation (postnatal day 0 (P0)∼), CFs creep among PC somata to form trans...
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ژورنال
عنوان ژورنال: Glia
سال: 2020
ISSN: 0894-1491,1098-1136
DOI: 10.1002/glia.23842